Review Article
MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications
Table 1
Characteristics of case-control studies included in the meta-analysis.
| | | | | | | | Genotype distribution | | | | | First author | Year | Country/region | Racial descent | Source of controls | Case | Control | Case | Control | Genotyping type | for HWE | MAF | Location | | | | | | | | CC | CT | TT | CC | CT | TT | | | | |
| Weinstein [12] | 2002 | Puerto Rico | Mixed | Population control | 135 | 146 | 67 | 53 | 15 | 69 | 62 | 15 | PCR-RFLP | 0.85 | 0.32 | Oral | Kureshi [20] | 2004 | Pakistan | Asian | NA | 50 | 54 | 32 | 18 | 0 | 32 | 18 | 4 | PCR-RFLP | 0.52 | 0.24 | HN | Neumann [21] | 2005 | USA | Caucasian | Hospital control | 537 | 545 | 258 | 244 | 35 | 278 | 216 | 51 | PCR-RFLP | 0.34 | 0.29 | HN | Capaccio [22] | 2005 | Italy | Caucasian | Population control | 65 | 100 | 18 | 33 | 14 | 36 | 46 | 18 | PCR-RFLP | 0.62 | 0.41 | HN | Vairaktaris [23] | 2006 | Greece | Caucasian | Population control | 110 | 120 | 28 | 76 | 6 | 45 | 65 | 10 | PCR-RFLP | 0.04 | 0.35 | Oral | Suzuki [24] | 2007 | Japan | Asian | Hospital control | 237 | 711 | 88 | 113 | 36 | 252 | 331 | 128 | TaqMan | 0.29 | 0.41 | HN | Reljic [25] | 2007 | Croatia | Caucasian | Population control | 81 | 102 | 45 | 27 | 9 | 35 | 59 | 8 | PCR-RFLP | 0.01 | 0.37 | HN | Hsiung [26] | 2007 | USA | Mixed | Population control | 277 | 524 | 128 | 149 | 218 | 306 | NA | NA | NA | HN | Hung [27] | 2007 | Europe | Caucasian | Hospital control | 779 | 2530 | 373 | 327 | 79 | 1272 | 1025 | 233 | TaqMan | 0.20 | 0.30 | HN | Solomon [28] | 2008 | India | Asian | NA | 126 | 100 | 48 | 55 | 23 | 48 | 42 | 10 | PCR-RFLP | 0.86 | 0.31 | Oral | Siraj [35] | 2008 | Saudi Arabia | Caucasian | Population control | 49 | 511 | 30 | 18 | 1 | 372 | 126 | 13 | PCR-RFLP | 0.55 | 0.15 | Thyroid | Ni [29] | 2008 | China | Asian | Hospital control | 207 | 400 | 48 | 95 | 64 | 152 | 187 | 61 | PCR-RFLP | 0.78 | 0.39 | Laryngeal | Rodrigues [36] | 2010 | Brazil | Mixed | Population control | 100 | 100 | 44 | 43 | 13 | 46 | 40 | 14 | PCR-RFLP | 0.28 | 0.34 | HN | Kruszyna [30] | 2010 | Poland | Caucasian | Population control | 131 | 250 | 69 | 52 | 10 | 126 | 104 | 20 | PCR-RFLP | 0.82 | 0.29 | Laryngeal | Cao [37] | 2010 | China | Asian | Population control | 511 | 552 | 310 | 169 | 32 | 334 | 188 | 30 | PCR-RFLP | 0.60 | 0.23 | NP | Tsai [31] | 2011 | Taiwan | Asian | Hospital control | 620 | 620 | 391 | 186 | 43 | 322 | 236 | 62 | PCR-RFLP | 0.06 | 0.29 | Oral | Supic [32] | 2011 | Serbia | Caucasian | Hospital control | 96 | 162 | 50 | 32 | 14 | 80 | 66 | 16 | PCR-RFLP | 0.66 | 0.30 | Oral | Sailasree [33] | 2011 | India | Asian | Hospital control | 101 | 138 | 92 | 8 | 1 | 108 | 29 | 1 | PCR-RFLP | 0.53 | 0.11 | Oral | Prasad [38] | 2011 | India | Asian | NA | 97 | 241 | 86 | 10 | 1 | 228 | 12 | 1 | PCR-RFLP | 0.07 | 0.03 | Thyroid | Fard-Esfahani [39] | 2011 | Iran | Asian | Hospital control | 154 | 198 | 69 | 71 | 14 | 82 | 108 | 8 | multiplex PCR | <0.01 | 0.31 | Thyroid | Ozdemir [40] | 2012 | Turkey | Caucasian | NA | 60 | 50 | 28 | 25 | 7 | 33 | 14 | 3 | Real-time PCR | 0.38 | 0.20 | Thyroid | Galbiatti [34] | 2012 | Brazil | Mixed | Population control | 322 | 531 | 130 | 147 | 45 | 226 | 250 | 55 | PCR-RFLP | 0.24 | 0.34 | HN | Vylliotis [41] | 2013 | Greek/Germany | Caucasian | Population control | 110 | 120 | 76 | 28 | 6 | 65 | 45 | 10 | PCR-RFLP | 0.58 | 0.27 | Oral |
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HWE in controls. MAF: minor allele frequency in controls. NA: not applicable. HN: head and neck. NP: nasopharyngeal.
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