MTHFR C677T Gene Polymorphism and Head and Neck Cancer Risk: A Meta-Analysis Based on 23 Publications

Table 2

Summary ORs and 95% CI of MTHFR C677T polymorphism and head and neck cancer risk.

	T versus C				TT versus CC				CT versus CC				CT + TT versus CC				TT versus CC + CT
	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)^a	OR	95% CI		(%)
Total	1.04	0.92–1.18	0.55	72.5	1.15	0.90–1.46	0.26	56.8	1.00	0.85–1.17	0.99	65.8	1.01	0.87–1.18	0.86	69.7	1.11	0.98–1.26	0.10	49.8
HWE	1.05	0.92–1.21	0.47	75.0	1.14	0.88–1.48	0.34	61.4	1.02	0.88–1.19	0.76	60.3	1.03	0.88–1.20	0.69	68.4	1.11	0.89–1.39	0.35	52.2
Ethnicity
Asian	1.03	0.78–1.36	0.83	86.0	1.29	0.73–2.28	0.38	79.6	0.96	0.73–1.25	0.75	70.8	1.00	0.74–1.36	0.99	80.4	1.28	0.80–2.06	0.30	74.0
Caucasian	1.39	0.89–1.20	0.65	49.1	1.04	0.85–1.27	0.66	0.0	1.04	0.81–1.35	0.75	69.5	1.05	0.83–1.33	0.67	66.3	1.01	0.84–1.22	0.90	0.0
Other	1.08	0.92–1.27	0.36	0.0	1.25	0.87–1.78	0.23	0.0	1.00	0.79–1.27	0.98	0.0	0.96	0.81–1.15	0.68	0.0	1.24	0.89–1.74	0.21	0.0
Design
PB	1.01	0.90–1.14	0.84	29.5	1.16	0.92–1.46	0.21	0.0	0.95	0.76–1.20	0.68	60.1	0.96	0.80–1.15	0.64	53.5	1.18	0.95–1.74	0.14	0.0
HB	0.98	0.77–1.25	0.86	87.9	1.09	0.69–1.74	0.71	82.9	0.94	0.72–1.22	0.72	79.1	0.96	0.72–1.27	0.76	84.3	1.07	0.72–1.58	0.74	79.2
Location
Oral	0.88	0.67–1.17	0.38	75.3	0.85	0.64–1.12	0.25	48.0	0.81	0.57–1.15	0.24	70.7	0.84	0.59–1.20	0.33	74.4	0.91	0.70–1.20	0.52	34.0
Laryngeal	1.33	0.68–2.60	0.40	90.6	1.82	0.51–6.44	0.353	86.1	1.22	0.70–2.13	0.48	70.5	1.37	0.63–3.00	0.43	86.8	1.64	0.64–4.17	0.30	77.9
Thyroid	1.30	1.03–1.65	0.04	43.9	2.06	1.04–4.10	0.04	0.0	1.48	0.84–2.62	0.17	65.9	1.53	0.92–2.53	0.10	60.5	2.02	1.04–3.92	0.04	0.0

Test for heterogeneity.
PB: population based; HB: hospital based.