Research Article
OGG1 Mutations and Risk of Female Breast Cancer: Meta-Analysis and Experimental Data
Table 6
Distribution and association of OGG1 mutations with smoking status in breast cancer patients.
| Mutation/exon
Chr3 (GRCh37) | Patients | | Smokers (%) | Nonsmokers (%) | ORa (95%CI), b value |
| | g.9792260 ins_T Intron 1 | 4 (4.6) | 30 (12.4) | 0.34 (0.12 to 1.0), 0.05 | | g.9793680G>A Intron 3 (rs55846930) | 5 (5.7) | 14 (5.8) | 1.0 (0.35 to 2.84), 1.0 | | g.9793748G>A Intron 3 | 1 (1.1) | 13 (5.4) | 0.2 (0.03 to 1.59), 0.13 | | g.9798336T>G Intron 5 | 2 (2.3) | 08 (3.3) | 0.7 (0.14 to 3.31), 0.64 | | g.9798349T>A Intron 5 | 5 (5.7) | 29 (12.0) | 0.45 (0.17 to 1.19), 0.1 | | g.9792109delT splice site Intron 1 | 14 (16.1) | 12 (5.0) | 3.67 (1.6 to 8.3), 0.002 | g.9798307T>G
Splice site Intron 5 | 0 | 16 (6.6) | 0.16 (0.02 to 1.26), 0.08 | g.9798502T>G
Splice site Intron 6 | 2 (2.3) | 16 (6.6) | 0.33 (0.07 to 1.48), 0.1 | g.9800972T>G
Splice site Intron 7a | 15 (17.2) | 21 (8.7) | 2.19 (1.07 to 4.48), 0.03 | | g.9798848G>A 3′UTR | 4 (4.6) | 33 (7.8) | 0.3 (0.1 to 0.88), 0.03 | | g.9798896T>C 3′UTR | 09 (10.3) | 39 (16.1) | 0.6 (0.28 to 1.3), 0.2 | | g.9793544T>G Exon 3, Val159Gly | 2 (2.3) | 16 (6.6) | 0.3 (0.07 to 1.47), 0.15 | | g.9796483G>A Exon 4, Gly221Arg (TMP_ESP_3_9796483) | 4 (4.6) | 18 (7.4) | 0.6 (0.2 to 1.8), 0.3 | g.9798773C>G Exon 6d, Ser326Cys
(rs1052133) (CM993185) | 17 (19.5) | 07 (2.9) | 8.1 (3.2 to 20.4), <0.0001 | | g.9807669G>A Exon 8 Trp375STOP | 3 (3.4) | 14 (5.8) | 0.6 (0.16 to 2.1), 0.4 |
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aOR: odds ratio; CI: confidence interval. aORs for logistic regression analysis. b is considered statistically significant, by -test for trend.
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