Prognostic Role of MicroRNA-126 for Survival in Malignant Tumors: A Systematic Review and Meta-Analysis

Table 2

Meta-analysis results.

Outcome	Variables	Number of studies	Number of patients	Model	HR (95% CI)	Heterogeneity		Publication bias
						(%)		Begg’s	Egger’s
OS	All	20	3232	Random	0.77 (0.64, 0.93)	56.8	0.001	0.381	0.358
	Tumor type
	NSCLC	4	613	Random	0.42 (0.17, 1.08)	82.2	0.001	1.000	0.340
	HCC	2	173	Fixed	0.65 (0.49, 0.86)	2.60	0.311
	CRC	5	896	Fixed	0.85 (0.69, 1.04)	0	0.584	0.806	0.679
	RCC	2	738	Fixed	0.65 (0.38, 1.12)	0	0.624
	AML	2	200	Fixed	1.77 (1.15, 2.72)	0	0.666
	Ethnicity
	Asian	12	1353	Fixed	0.76 (0.66, 0.88)	37.0	0.129	0.837	0.668
	Caucasian	8	1879	Random	0.77 (0.57, 1.05)	73.8	<0.001	0.536	0.479
	Sample
	Circulation	4	273	Fixed	1.65 (1.09, 2.51)	0	0.647	0.734	0.162
	Tissue	16	2959	Random	0.71 (0.60, 0.85)	51.1	0.01	0.137	0.068
	Assay method
	qRT-PCR	17	2940	Random	0.72 (0.58, 0.90)	61.2	<0.001	0.303	0.250
	ISH	3	292	Fixed	1.00 (0.75, 1.34)	0	0.804	1.000	0.646
	Analysis type
	Multivariate	7	1870	Fixed	0.81 (0.72, 0.90)	11.0	0.344	0.072	0.095
	Univariate	7	1530	Random	0.89 (0.79, 1.00)	66.4	0.007	1.000	0.990
	HR estimated
	HRs reported	14	2897	Random	0.78 (0.64, 0.96)	67.8	<0.001	0.274	0.461
	K-M curve	6	335	Fixed	0.79 (0.53, 1.18)	0	0.666	1.000	0.705
DFS	All	7	755	Fixed	0.64 (0.48, 0.85)	0	0.780	0.133	0.203
	Tumor type
	NSCLC	2	101	Fixed	0.49 (0.26, 0.93)	0	0.983
	ESCC	2	274	Fixed	0.77 (0.48, 1.24)	0	0.629
	Ethnicity
	Asian	4	417	Fixed	0.64 (0.44, 0.94)	0	0.532	0.308	0.081
	Caucasian	3	419	Fixed	0.63 (0.41, 0.97)	0	0.599	1.000	0.874
	Analysis type
	Multivariate	3	509	Fixed	0.65 (0.45, 0.94)	0	0.384	0.296	0.360
	Univariate	4	619	Random	0.67 (0.50, 0.90)	88.0	<0.001	0.734	0.586
RFS/PFS/DSS	All	13	2014	Random	0.70 (0.50, 0.98)	84.8	<0.001	0.360	0.288
	Tumor type
	CRC	5	882	Fixed	0.74 (0.59, 0.94)	47.3	0.108	1.000	0.514
	NSCLC	2	382	Random	0.43 (0.03, 7.25)	97.2	<0.001
	Ethnicity
	Asian	2	313	Fixed	0.69 (0.48, 0.99)	0	0.417
	Caucasian	11	1701	Random	0.69 (0.46, 1.02)	87.1	<0.001	0.213	0.267
	Analysis type
	Multivariate	7	1531	Random	0.71 (0.50, 1.02)	83.2	<0.001	0.230	0.281
	Univariate	5	651	Random	0.89 (0.77, 1.02)	81.4	<0.001	0.462	0.872

CRC: colorectal cancer; HCC: hepatocellular carcinoma, NSCLC: non-small cell lung cancer; cRCC: clear renal cell carcinoma; ESCC: esophageal squamous cell carcinoma; AML: acute myeloid leukemia; K-M curve: Kaplan-Meier curve; fixed: fixed-effects model; random: random-effects model.