The Influence of Vitamin D Receptor Genetic Variants on Bone Mineral Density and Osteoporosis in Chinese Postmenopausal Women
Table 3
The characteristics of VDR genetic variants in the studied subjects.
SNPs
p.Gly14Ala
p.His305Gln
Genotype
GG
GC
CC
CC
CG
GG
Number (%)
440 (0.4536)
418 (0.4309)
112 (0.1155)
—
487 (0.5021)
383 (0.3948)
100 (0.1031)
—
Age (years)
62.2 ± 7.2
62.5 ± 7.3
62.9 ± 6.9
0.553
61.9 ± 7.8
62.8 ± 7.0
62.9 ± 7.5
0.462
Height (cm)
161 ± 7.8
163 ± 6.8
164 ± 6.9
0.438
158 ± 7.8
162 ± 6.2
164 ± 6.9
0.538
Weight (kg)
62.4 ± 6.3
62.6 ± 6.5
62.8 ± 6.1
0.329
61.9 ± 7.7
62.7 ± 6.5
62.9 ± 6.5
0.365
BMI
23.2 ± 3.28
23.4 ± 3.35
23.7 ± 3.42
0.452
23.3 ± 3.67
23.6 ± 3.41
23.7 ± 3.53
0.239
Lumbar spine BMD (g/cm2)
0.932 ± 0.117
0.827 ± 0.122
0.822 ± 0.119
0.018
0.925 ± 0.113
0.832 ± 0.120
0.828 ± 0.126
0.028
Femoral neck hip BMD (g/cm2)
0.751 ± 0.125
0.687 ± 0.119
0.679 ± 0.128
0.037
0.749 ± 0.202
0.681 ± 0.197
0.679 ± 0.211
0.027
Total hip BMD (g/cm2)
0.865 ± 0.134
0.817 ± 0.156
0.809 ± 0.129
0.028
0.861 ± 0.129
0.820 ± 0.219
0.813 ± 0.172
0.048
Note: VDR: vitamin D receptor; SNPs: single nucleotide polymorphisms; BMD: bone mineral density; BMI: body mass index; Data are shown as mean ± SD (BMD values adjusted by age, weight, and height).
