CD73 Predicts Favorable Prognosis in Patients with Nonmuscle-Invasive Urothelial Bladder Cancer

Table 3

Analysis of factors for tumor progression.

Variable	Categorization	Tumor progression (TP)
			Events
Pathologic data
Tumor stage (WHO 1973)	pTa	90	10	0.360
	pT1	68	12
Histologic grade (WHO 1973)	G1	44	3	0.085
	G2	86	12
	G3	28	7
Histologic grade (WHO 2004)	Low grade	99	10	0.083
	High grade	59	12
Adjacent carcinoma in situ	No	146	20	0.545
	Yes	12	2
Multifocality	Unifocal tumor	115	15	0.465
	Multifocal tumor	43	7
Growth pattern	Papillary	151	17	<0.0001
	Solid	7	5
Immunohistochemistry
CD73	Score 0 or 1+	114	20	0.030
	Score 2+	44	2
Ki-67 labelling index	≤10%	106	9	0.003
	>10%	52	13

Only primary pTa and pT1 tumors are included.
Log-rank test (2-sided); bold face representing values <0.05.
Staging and grading according to the 1973 WHO classification system.
Staging and grading according to the 2004 WHO classification system.