Polymorphism on Chromosome 9p21.3 Is Associated with Severity and Early-Onset CAD in Type 2 Diabetic Tunisian Population

Table 2

Changes in biochemical measurements and clinical characteristics among the three genotypes in the three groups of the diabetic population.

	Rs1333049
	GG ()	GC ()	CC ()
Gender: male/female (%)	31/38	54,8/45,2	56,4/43,6	0,314
Age (years)	62,04 ± 13,66	62,22 ± 12,91	64,46 ± 9,59	0,037
Family history for CAD (%)	56,5	50	80,8	<0,001
Hypertension (%)	52,2	59,5	65,4	0,026
BMI	28,24 ± 4,23	29,24 ± 4,73	31,34 ± 3,84	<0,001
Obesity (%)	30,4	40,5	73,1	<0,001
HbA1c (mmol/L)	10,24 ± 3,73	10,32 ± 4,23	11,08 ± 4,53	0,379
Smoking (%)	36,2	38,1	53,8	0,045
Cholesterol (mmol/L)	4,89 ± 1,17	4,56 ± 1,19	4,83 ± 0,93	0,081
LDL (mmol/L)	3,53 ± 1,34	3,73 ± 1,48	3,91 ± 1,49	0,028
HDL (mmol/L)	1,37 ± 0,65	1,19 ± 0,48	1,19 ± 0,44	0,06
TG (mmol/L)	1,87 ± 1	2,13 ± 1,21	2,66 ± 1,52	0,001
Hyperlipidemia (%)	18,8	42,1	88,5	<0,001
Insulin (%)	44,9	47,6	66,7	0,011

Data are number (%) and mean ± SD. BMI: body mass index; CAD: coronary artery disease; HbA1c: glycosylated hemoglobin; HDL-C: HDL cholesterol; LDL-C: LDL cholesterol; TC: cholesterol total; TG: triglycerides.