Genome-Wide Scan for Methylation Profiles in Keloids

Figure 1

(a) Methylation status of the 685 differentially methylated CpGs (cytosine-phosphodiester bond-guanine) at Tier 3 (26% hypermethylated, 74% hypomethylated). (b) 685-CpG distributions in promoter versus nonpromoter (28% promoter, 72% nonpromoter). (c) Methylation status of 190 promoter CpGs (33% hypermethylated, 67% hypomethylated). (d) 190-CpG distribution in promoter regions (41% 5′UTR, 29% TSS200, 26% TSS1500, and 4% 1st exon). (e) Methylation status of 152 genes associated with the 190 CpGs (37% hypermethylated, 63% hypomethylated).

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