Review Article
Liquid Biopsy of Hepatocellular Carcinoma: Circulating Tumor-Derived Biomarkers
Table 1
Summary of the role and findings for circulating DNA in HCC.
| Type of alteration | Gene | Location | Biomarker | References |
| Single nucleotide mutations | TP53 | 17p13.1 | Diagnosis | [14–16] | CTNNB1 | 3p21 | Predictor (exposure to different viral and environmental factors) | [17] |
| Copy number variation | NA | 1p/1q/8p/8q | Diagnosis | [18] | NA | 7q/8q/13q/14p | Diagnosis | [19] | NA | 1q, 8q, 7q, 17q, 20q | Diagnosis | [20–22] | NA | 4q, 8p, 13q, 16q, 17p | Diagnosis | [20–22] | CHD1L | 1q21 | Diagnosis | [23] | DLC1 | 8p22 | Diagnosis | [24] |
| Methylation changes | APC | 5q21-q22 | Diagnosis | [25, 26] | P15/P16 | 9p21 | Diagnosis | [25, 27] | RASSF1A | 3p21.3 | Diagnosis | [28] | TRG5 | 16q22.1 | Diagnosis | [29] | HOXA9 | 7p15.2 | Diagnosis | [30] | FHIT | 3p14.2 | Diagnosis | [25] | E-caherin | 16q22.1 | Diagnosis | [25] | GSTP1 | 11q13.2 | Diagnosis | [31] | SFRP1 | 8p11.21 | Diagnosis | [31] |
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NA: not available.
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