Research Article
Association of Plasma IL-32 Levels and Gene Polymorphisms with Systemic Lupus Erythematosus in Chinese Han Population
Table 3
Distribution of IL-32 SNPs in SLE patients and healthy controls and their association with SLE susceptibility.
| | Model | rs28372698 | rs12934561 | | Genotype | Controls | Patients | OR (95% CI) | value | Genotype | Controls | Patients | OR (95% CI) | value | | | | |
| | Codominant | AA | 150 (0.484) | 69 (0.454) | 1.00 (reference) | 0.038 | TT | 103 (0.332) | 63 (0.414) | 1.00 (reference) | 0.189 | | AT | 141 (0.455) | 63 (0.414) | 0.97 (0.64–1.47) | TC | 149 (0.481) | 61 (0.401) | 0.67 (0.43–1.03) | | TT | 19 (0.061) | 20 (0.132) | 2.29 (1.15–4.56) | CC | 58 (0.187) | 28 (0.184) | 0.79 (0.46–1.37) | | Dominant | AA | 150 (0.484) | 69 (0.454) | 1.00 (reference) | 0.545 | TT | 103 (0.322) | 63 (0.414) | 1.00 (reference) | 0.084 | | AT/TT | 160 (0.516) | 83 (0.546) | 1.13 (0.76–1.67) | TC/CC | 207 (0.668) | 89 (0.586) | 0.70 (0.47–1.05) | | Recessive | AA/AT | 291 (0.939) | 132 (0.868) | 1.00 (reference) | 0.011 | TT/TC | 252 (0.813) | 124 (0.816) | 1.00 (reference) | 1.000 | | TT | 19 (0.061) | 20 (0.132) | 2.32 (1.20–4.50) | CC | 58 (0.187) | 28 (0.184) | 0.98 (0.60–1.62) | | Overdominant | AA/TT | 169 (0.545) | 89 (0.586) | 1.00 (reference) | 0.411 | TT/CC | 161 (0.519) | 91 (0.6) | 1.00 (reference) | 0.108 | | AT | 141 (0.455) | 63 (0.414) | 0.85 (0.57–1.26) | TC | 149 (0.481) | 61 (0.4) | 0.72 (0.49–1.07) | | | Allele | | | | | | | | | | | | A | 441 (0.711) | 201 (0.661) | 1.26 (0.94–1.70) | 0.129 | T | 355 (0.573) | 187 (0.615) | 0.84 (0.63–1.11) | 0.217 | | | T | 179 (0.289) | 103 (0.339) | | C | 265 (0.427) | 117 (0.385) | |
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Notes. , the number of individuals. Statistically significant.
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