Human Hemochromatosis Protein (HFE) Immunoperoxidase Stain Highlights Choriocarcinoma within Mixed Germ Cell Tumors
Table 1
Demographics of patients included in this study.
1
2
Tissue source
Age
Gender
Diagnosis
+
Placenta
44
Female
Third trimester placenta (371 g, less than 10th percentile for gestational age) without histologic abnormality
+
Placenta
35
Female
Third trimester placenta (410 g, 10th–25th percentile for gestational age) without histologic abnormality
+
Placenta
39
Female
Third trimester placenta (526 g, 10th–25th percentile for gestational age) without histologic abnormality
+
Placenta
29
Female
Third trimester placenta (311 g, less than 10th percentile for gestational age) without histologic abnormality
+
Placenta
25
Female
Third trimester placenta (392 g, 10th–25th percentile for gestational age) without histologic abnormality
+
Placenta
19
Female
Third trimester placenta (447 g, 10th–25th percentile for gestational age) without histologic abnormality
+
Products of conception
36
Female
Complete hydatidiform mole
+
Uterus, evacuation
46
Female
Complete hydatidiform mole
+
Products of conception
22
Female
Complete hydatidiform mole
+
Products of conception
25
Female
Features consistent with partial hydatidiform mole
+
Uterine contents
26
Female
Hydropic chorionic villi with modest gestational trophoblastic proliferation
+
Periaortic mass
23
Male
Cystic trophoblastic proliferation
+
Brain, frontal lobe, right
24
Male
Metastatic choriocarcinoma
+
Lung, left upper lobe nodule
25
Male
Metastatic choriocarcinoma
+
Brain, occipital lobe, and dura
17
Male
Metastatic mixed germ cell tumor composed of embryonal carcinoma and yolk sac tumor with focal choriocarcinoma
+
Lung, right upper lobe nodule
24
Male
Metastatic choriocarcinoma
+
Testicle, left mass biopsy
29
Male
Mixed germ cell tumor composed of embryonal carcinoma (50%), teratoma (45%), and choriocarcinoma (5%)
+
Testicle, right
17
Male
Mixed germ cell tumor composed of embryonal carcinoma (70%), teratoma (20%), yolk sac tumor (5%), and choriocarcinoma (5%)
+
Testicle, right
54
Male
Mixed germ cell tumor composed of yolk sac tumor (60%), teratoma (20%), embryonal carcinoma (10%), seminoma (5%), and choriocarcinoma (5%)
+
Inguinal mass
28
Male
Mixed germ cell tumor composed of seminoma (40%), embryonal carcinoma (30%), and choriocarcinoma (<1%)
Testicle, left
34
Male
Classic seminoma
Testicle, left
65
Male
Classic seminoma
Testicle, right
35
Male
Classic seminoma
Testicle, left
38
Male
Classic seminoma
Testicle, left
31
Male
Mixed germ cell tumor composed of seminoma (90%) and embryonal carcinoma (10%)
Testicle, right
24
Male
Mixed germ cell tumor composed of teratoma (50%), embryonal carcinoma (25%), and yolk sac tumor (25%)
Testicle, right
20
Male
Mixed germ cell tumor composed of embryonal carcinoma (>85%), yolk sac tumor (<10%), and teratoma (<10%)
Testicle, left
23
Male
Mixed germ cell tumor composed of embryonal carcinoma (99%) and teratoma (1%)
Testicle, right
32
Male
Mixed germ cell tumor composed of embryonal carcinoma (95%) and yolk sac tumor (5%)
Testicle, right
48
Male
Mixed germ cell tumor composed of yolk sac tumor (95%), seminoma (5%), and embryonal carcinoma (<1%)
The patients included in this study are summarized in the table. Information includes tissue source, age, gender, and primary diagnosis. An asterisk () in the column designated “1” denotes samples obtained from the same patient. A plus symbol (+) in the column designated “2” denotes samples with prominent HFE staining. Rows in italic font are shown in Figure 1. Rows in bold font designate tissues included in Figures 2 and 3.
