Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions

Figure 1

DOG1 expression in different breast lesions. (a) DOG1 was consistently expressed in normal duct and acini MECs (×200); the luminal epithelium showed randomly positive DOG1 expression in an apical-luminal membranous pattern with less intensity (arrow, ×400). Stromal cells were mostly negative. (b) DOG1 staining in MECs in adenosis (×200). (c) DOG1 was consistently positive in MECs in cases of fibroadenoma (×200). (d) DOG1 expression was positive in the duct in atypical ductal hyperplasia, but there was no DOG1 staining in atypical hyperplastic luminal cells (×200). (e) DOG1 staining in adenomyoepithelioma. There was negligible staining in both MECs and luminal epithelial cells (×400). (f) DOG1 staining in adenoid cystic carcinoma. There was negligible staining in MECs (×200).