Research Article
Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer
Table 4
Correlation between OSR2, VAV3, and PPFIA3 hypermethylation status in serum of GC patients and clinicopathological parameters.
| Parameters | Number of cases | OSR2 | VAV3 | PPFIA3 | Methylation | value | Methylation | value | Methylation | value |
| Age | | | | | | | | <60 | 26 | 16 (61.5%) | 0.881 | 13 (50.0%) | 0.529 | 14 (53.8%) | 0.715 | ≥60 | 22 | 14 (63.6%) | 9 (40.9%) | 13 (59.1%) | Gender | | | | | | | | Male | 39 | 23 (59.0%) | 0.504 | 19 (48.7%) | 0.186 | 23 (59.0%) | 0.675 | Female | 9 | 7 (77.8%) | 3 (33.3%) | 4 (44.4%) | Pathological differentiation | | | | | | | | Well + moderate | 19 | 13 (68.4%) | 0.493 | 7 (36.8%) | 0.583 | 11 (57.9%) | 0.853 | Poor + undifferentiation | 29 | 17 (58.6%) | 13 (44.8%) | 16 (55.2%) | Depth of tumor invasion | | | | | | | | Tis, T1a, T1b | 5 | 2 (40.0%) | 0.663 | 2 (40.0%) | 0.645 | 2 (40.0%) | 0.694 | T2 | 7 | 5 (71.4%) | 2 (28.6%) | 3 (42.9%) | T3 | 12 | 7 (58.3%) | 7 (58.3%) | 7 (58.3%) | T4a, T4b | 24 | 16 (66.7%) | 11 (45.8%) | 15 (62.4%) | Lymph node metastasis | | | | | | | | N0 | 16 | 9 (56.3%) | 0.492 | 5 (31.3%) | 0.430 | 8 (50.0%) | 0.514 | N1 | 15 | 8 (53.3%) | 7 (46.7%) | 7 (46.7%) | N2 | 6 | 5 (83.3%) | 4 (66.7%) | 4 (66.7%) | N3a, N3b | 11 | 8 (72.7%) | 6 (54.5%) | 8 (72.7%) | TNM stages | | | | | | | | I and II | 22 | 13 (59.1%) | 0.881 | 8 (36.4%) | 0.019 | 10 (45.5%) | 0.165 | III and IV | 26 | 17 (65.4%) | 14 (53.8%) | 17 (65.4%) |
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Using chi-square for this statistic. Statistically significant.
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