Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer

Table 3

Nonpathogenic variants found among younger Algerian women.

Patients	Genes	Age at diagnosis	Sequence variant	Consequence	Interpretation	Affected member family
						Breast or ovarian cancers (age at diagnosis: years)	Other cancer (age at diagnosis: years)
760	BRCA1	39	c.5117G>C	(p.Gly1706Ala)	FP	No	Uncle M, liver; 2 aunts P, blood (75, 80)
769	BRCA2	40	c.7462A>G	(p.Arg2488Gly)	VUCS	Mother, breast (62)	No
772	BRCA2; BRCA1	39	c.1504A>C	(p.Lys502Gln)	VUCS	Sister, breast (23)	No
			c.5117G>C	(p.Gly1706Ala)	FP
789	BRCA2	40	c.5939C>T	(p.Thr1980Ile)	VUCS	No	No
798	BRCA2	39	c.1627C>A	(p.His543Asn)	VUCS	No	Father, lung (76)

FP: favor polymorphism, M: maternal, P: paternal, VUCS: variant of uncertain clinical significance.