HER2 Protein Overexpression and Gene Amplification in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder

Figure 1

Plasmacytoid component of case 1 (a) showed diffuse 3+ HER2 IHC positivity (b) and HER2 gene amplification (HER2/CEP17 ratio 5.8) by FISH (c). Case (d) was negative for HER2 by IHC (e), but the HER2 gene was amplified (HER2/CEP17 ratio 2.06) (f). Case (g) showed 2+ HER2 by IHC (h) and equivocal HER2 FISH results (HER2/CEP17 ratio 1.81 and average HER2 gene copy number 4.9) (i).

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