Research Article
HER2 Protein Overexpression and Gene Amplification in Plasmacytoid Urothelial Carcinoma of the Urinary Bladder
Table 2
HER2 IHC and FISH results.
| Case | Component | HER2 IHC | HER2 gene amplification | HER2/CEP17ā ratio | Average HER2ā copy number |
| 1 | P | Positive (3+) | Positive | 5.8 | 20.0 | CONV | Positive (3+) | Positive | 3.03 | 9.0 |
| 2 | P | Positive (3+) | Positive | 3.61 | 9.8 | MP | Positive (3+) | Positive | 2.2 | 9.0 | CONV | Positive (3+) | Positive | 2.13 | 7.5 |
| 3 | P | Negative (0) | Positive | 2.06 | 4.9 | CONV | Negative (0) | Negative | 1.27 | 2.0 |
| 4 | P | Equivocal (2+) | Equivocal | 1.81 | 4.9 |
| 5 | P | Positive (3+) | Negative | 1.68 | 3.5 |
| 6 | P | Positive (3+) | Equivocal | 1.61 | 4.5 | CONV | Positive (3+) | Negative | 1.07 | 3.2 |
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P, plasmacytoid component; CONV, conventional component; MP, micropapillary component.
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