Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

Figure 3

Relative expression of a vector containing the rs284510654 A allele and rs28451064 G allele normalised to the pGL3 promoter expression. Relative expression was compared using paired -tests. Both plasmids containing the sequence surrounding rs28451064 showed higher expression (A allele 87% higher = 1.90 × 10⁻¹⁵, G allele 62% higher = 9.74 × 10⁻¹⁵). The A allele was found to have 12% higher expression compared to the G allele ( = 4.82 × 10⁻³).