Research Article
Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22
Table 1
The association between four SNPs at the CHD risk locus on chromosome 21q22 and mean QT interval in UCLEB.
| | SNP | | | Beta coefficient | value |
| | rs9982601 | Genotype | CC | TC | TT | 1.83 (0.90) | 0.04 | | (frequency) | 5329 (0.75) | 1643 (0.23) | 130 (0.02) | | Mean QT interval (ms) | 402.8 (37.35) | 404.5 (39.28) | 409.1 (41.08) |
| | rs8131284 | Genotype | TT | CT | CC | 2.14 (0.89) | 0.02 | | (frequency) | 5293 (0.75) | 1670 (0.24) | 142 (0.02) | | Mean QT interval (ms) | 402.7 (37.41) | 404.9 (39.20) | 408.1 (38.97) |
| | rs7278204 | Genotype | AA | GA | GG | 2.07 (0.89) | 0.02 | | (frequency) | 5290 (0.74) | 1673 (0.24) | 141 (0.02) | | Mean QT interval (ms) | 402.7 (37.73) | 404.9 (38.19) | 407.9 (39.26) |
| | rs973754 | Genotype | AA | GA | GG | 1.85 (0.89) | 0.02 | | (frequency) | 5300 (0.75) | 1663 (0.23) | 142 (0.02) | | Mean QT interval (ms) | 402.7 (37.75) | 404.6 (38.18) | 408.2 (38.84) |
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Mean QT interval is shown by genotype as well as the beta coefficient (±standard deviation) for the minor allele at each SNP.
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