Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer

Figure 5

Downregulation of GRK3 expression inhibits tumorigenicity in vivo. (a) Stable GRK3 knockdown clones and control clones of RKO cells were injected subcutaneously into the flank of nude mice. (b) The tumor volume was calculated once 5 days. (c) All mice were euthanized 21 days after inoculation, and their tumors were weighed. Data are expressed as mean ± standard deviation. indicate statistical significance between shRNA-GRK3 and the control group. Statistical comparisons were made using two-tailed unpaired t-test.

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