Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer

Table 2

Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS).

Variable	Univariate analysis			Multivariate analysis
	HR	CI (95%)	value	HR	CI (95%)	value
Age
<65 years	1	—
≥65 years	0.611	0.374–0.998	0.051
Gender
Male	1	—
Female	1.070	0.667–1.714	0.780
AJCC stage
I and II	1	—		1	—
III and IV	0.364	0.225–0.590	<0.001	0.458	0.277–0.756	0.002
T stage					NR
T1 and T2	1	—
T3 and T4	0.342	0.138–0.851	0.021
Lymph node metastasis					NR
Negative	1	—
Positive	0.418	0.260–0.672	<0.001
Distant metastasis					NR
M0	1	—
M1	0.144	0.075–0.276	<0.001
Differentiation
Well and moderate	1	—		1	—
Poor	0.451	0.279–0.728	0.001	0.539	0.329–0.883	0.014
GRK3 expression
Negative	1	—		1	—
Weak and strong	0.375	0.201–0.698	0.002	0.424	0.226–0.797	0.008

HR: hazard radio; CI: confidence interval; NR: variable was not included in the resultant model. Significance indicated that the 95% CI of HR was not including 1.