Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer
Table 2
Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS).
Variable
Univariate analysis
Multivariate analysis
HR
CI (95%)
value
HR
CI (95%)
value
Age
<65 years
1
—
≥65 years
0.611
0.374–0.998
0.051
Gender
Male
1
—
Female
1.070
0.667–1.714
0.780
AJCC stage
I and II
1
—
1
—
III and IV
0.364
0.225–0.590
<0.001
0.458
0.277–0.756
0.002
T stage
NR
T1 and T2
1
—
T3 and T4
0.342
0.138–0.851
0.021
Lymph node metastasis
NR
Negative
1
—
Positive
0.418
0.260–0.672
<0.001
Distant metastasis
NR
M0
1
—
M1
0.144
0.075–0.276
<0.001
Differentiation
Well and moderate
1
—
1
—
Poor
0.451
0.279–0.728
0.001
0.539
0.329–0.883
0.014
GRK3 expression
Negative
1
—
1
—
Weak and strong
0.375
0.201–0.698
0.002
0.424
0.226–0.797
0.008
HR: hazard radio; CI: confidence interval; NR: variable was not included in the resultant model. Significance indicated that the 95% CI of HR was not including 1.