Plasma Fibulin-3 as a Potential Biomarker for Patients with Asbestos-Related Diseases in the Han Population

Table 3

AUC and cutoff value of plasma fibulin-3 for diagnosing ARDs.

	AUC (95% CI)	Cutoff value (ng/ml)	Sensitivity (%)	Specificity (%)	value
MPM versus control	0.92 (0.81–1.00)	15.30	86.67	97.87	<0.001
MPM versus AE	0.88 (0.75–1.00)	15.84	86.67	91.89	<0.001
MPM versus PP	0.90 (0.78–1.00)	15.86	86.67	93.58	<0.001
MPM versus asbestosis	0.81 (0.67–0.96)	15.69	86.67	75.86	0.001
Asbestosis versus controls	0.67 (0.55–0.79)	14.88	31.03	97.87	0.007
AE versus controls	0.61 (0.53–0.70)	12.26	41.89	77.66	0.014
PP versus controls	0.57 (0.50–0.64)	8.40	90.83	23.40	0.040

AUC: area under the curve; CI: confidence interval; PP: pleural plaque; MPM: malignant pleural mesothelioma; AE: asbestos-exposed subjects; ARDs: asbestos-related diseases.