MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis

Figure 3

Forest plots showing multivariate Cox regression analyses of the effect of miR-155-5p expression status and clinicopathological and biological variables on the OS of CLL patients. The multivariate models were adjusted for the CD38 expression status, presence of IGHV mutations, and either clinical stage (Binet or Rai) or risk group. These two staging systems share common components (enlarged lymph node areas, anemia, and low levels of platelets), and risk classification is based on Rai staging; consequently, these three prognosticators cannot be included in the same multivariate Cox regression model. Diamonds indicate the hazard ratios, and horizontal lines represent the 95% confidence interval of each hazard ratio.