Phosphorylation of Histone H2A.X in Peripheral Blood Mononuclear Cells May Be a Useful Marker for Monitoring Cardiometabolic Risk in Nondiabetic Individuals

Table 1

General characteristics and metabolic risk-related biochemical parameters of the study subjects.

	Super healthy ()	MetS risk ()
Age (year)	45.9 ± 1.24	54.9 ± 1.56^+
Male, n (%)	7 (10.0)	17 (35.4)^+
Cigarette (n/day)	1.34 ± 0.57	5.73 ± 2.00^+
Alcohol (g/week)	20.8 ± 2.80	38.0 ± 10.9^+
BMI (kg/m^2)	21.9 ± 0.27	25.9 ± 0.48
Waist (cm)	72.4 ± 0.77	84.8 ± 1.47
Systolic BP (mmHg)	109.8 ± 0.99	120.3 ± 1.74
Diastolic BP (mmHg)	69.7 ± 0.70	74.1 ± 1.07
Glucose (mg/dL)	85.4 ± 0.82	100.1 ± 2.21
HbA1C (%)	5.17 ± 0.04	5.65 ± 0.08
Triglyceride (mg/dL)	67.6 ± 3.48	144.7 ± 11.9
HDL cholesterol (mg/dL)	69.5 ± 1.50	52.9 ± 1.97
LDL cholesterol (mg/dL)	115.0 ± 3.05	132.6 ± 5.30
Total cholesterol (mg/dL)	187.7 ± 2.92	202.0 ± 6.13

Data are . or percentage (%); tested after log-transformed, ⁺; tested by Student’s t-test or chi-square method, ; tested by general linear model method adjusted for age sex, cigarette smoking, and alcohol consumption. AST: aspartate aminotransferase; ALT: alanine aminotransferase; BMI: body mass index; BP: blood pressure; BUN: blood urea nitrogen; Hb_A1C: hemoglobin A1C.