The Immunosignature of Mother/Fetus Couples in Gestational Diabetes Mellitus: Role of HLA-G 14 bp ins/del and PAPP-A A/C Polymorphisms in the Uterine Inflammatory Milieu

Table 3

Distribution of the HLA-G 14 bp insertion/deletion (ins/del) and PAPP-A A/C genotypic combinations among GDM mothers and children versus the controls. OR: odds ratio; 95% CI: 95% confidence interval.

Genotype combinations	PAPP-A A/C	GDM mothers ()		Healthy mothers ()		OR (95% CI)
		N	%	N	%
HLA-G 14 bp ins/del
del/del	AA	2	8	19	13	Reference
	AC	3	12	19	13	1.5 (0.2–10.0)	0.62
	CC	2	8	2	1.3	9.5 (0.8–109)	0.07
del/ins	AA	6	25	37	24	1.54 (0.3–8.4)	0.50
	AC	7	29	33	22	2.0 (0.4–10.7)	0.68
	CC	0	0	5	3	Undetermined
ins/ins	AA	0	0	18	12	Undetermined
	AC	3	12	14	9	2.0 (0.3–13.8)	0.47
	CC	1	4	4	3	2.4 (0.2–33.0)	0.52
Genotype combinations	PAPP-A A/C	Children born to GDM mothers ()		Children born to healthy mothers ()		OR (95% CI)
		N	%	N	%
HLA-G 14 bp ins/del
del/del	AA	2	10	11	8	Reference
	AC	4	20	16	12	1.4 (0.2–8.8)	0.74
	CC	2	10	4	3	2.8 (0.3–26.7)	0.38
del/ins	AA	7	35	40	30	1.0 (0.2–5.3)	0.96
	AC	1	5	29	21	0.2 (0–2.3)	0.19
	CC	0	0	3	2	Undetermined
ins/ins	AA	1	5	15	11	0.4 (0–4.6)	0.44
	AC	2	10	13	10	0.8 (0.1–7.0)	0.88
	CC	1	5	4	3	1.4 (0.1–19.6)	0.81