Expression of AdipoR1 and AdipoR2 Receptors as Leptin-Breast Cancer Regulation Mechanisms

Figure 5

Units of relative expression of AdipoR1 and AdipoR2. The data is expressed as mean ± SD. In MCF-7 breast cancer cells, there is a 2.92% decrease in the expression of AdipoR1 (a) in cells treated with leptin (100 ng/mL) with regard to the control and of 3.81% for the concentration of 1000 ng/mL, except at 10 ng/mL, where there was a 64.03% increase; the expression of AdipoR2 (b) increased by 13.74 times in cells treated with leptin (10 ng/mL) with regard to the control, 9.23 times for 100 ng/mL, and 11.39 times for 1000 ng/mL, finding significant differences compared to the control in all concentrations. With regard to the HCC1937 breast cancer cells, the expression of AdipoR1 (c) presented an 86.28% decrease in cells treated with leptin (10 ng/mL) with regard to the control, 13.72% (100 ng/mL), and 77.14% (1000 ng/mL), finding significant differences for 10 g/mL and 1000 ng/mL; the expression of AdipoR2 (c) exhibited a 24.4% decrease in cells treated with leptin (10 ng/mL), with regard to the control, 50.3% (100 ng/mL), and 26.2% (1000 ng/mL); however, no significant differences were found in any of the concentrations relative to control. Significant differences compared to the control (U of Mann–Whitney, ).

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