Role of MMP-1 (-519A/G, -1607 1G/2G), MMP-3 (Lys45Glu), MMP-7 (-181A/G), and MMP-12 (-82A/G) Variants and Plasma MMP Levels on Obesity-Related Phenotypes and Microvascular Reactivity in a Tunisian Population
Table 2
Anthropometric, biochemical, and microvascular parameters of the study subjects.
Parameters
All subjects
Obesity status
Classes of obesity
Nonobese (18.5 ≤ BMI < 25)
Obese (BMI ≥ 30)
Nonmorbidly obese
Morbidly obese
Class I (30 ≤ BMI < 35)
Class II (35 ≤ BMI < 40)
Class III (BMI ≥ 40)
Anthropometric measurements
BMI (kg/m2)
30 ± 0.44
22.87 ± 0.13
37.69 ± 0.5
32.16 ± 0.14
37.59 ± 0.21§
45.78 ± 0.75#,ǂ
WC (cm)
99.61 ± 1.2
79.93 ± 0.71
115.63 ± 1.06
105.69 ± 0.93
117.33 ± 1.37§
128.16 ± 1.6#,ǂ
HC (cm)
110.4 ± 1.06
95.07 ± 0.72
123.31 ± 1.12
113.82 ± 0.96
121.33 ± 1.65§
137.13 ± 1.6#,ǂ
WHRratio
0.89 ± 0.005
0.84 ± 0.08
0.93 ± 0.006
0.92 ± 0.009
0.97 ± 0.01§
0.93 ± 0.11
WHtRratio
0.6 ± 0.007
0.47 ± 0.004
0.7 ± 0.006
0.63 ± 0.005
0.71 ± 0.008§
0.8 ± 0.008 #,ǂ
Clinical measurements
SBP (mmHg)
121.6 ± 0.8
116.5 ± 0.58
126.4 ± 1.34
126.5 ± 1.85
128.6 ± 3.4
125.1 ± 2.3
DBP (mmHg)
79.4 ± 0.47
77 ± 0.43
81.8 ± 0.8
81.3 ± 1
82.4 ± 2
82.2 ± 1.35
MAP
79.05 ± 0.19
84.4 ± 1.81
74.73 ± 3.06
69.8 ± 0.47
74.64 ± 0.7
82 ± 4.67
Biochemical parameters
hs-CRP (mg/dl)
3.7 ± 0.28
1.25 ± 0.18
5.79 ± 0.42
4.58 ± 0.52
5.45 ± 0.89
7.42 ± 0.82#
FG (mmol/l)
5.46 ± 0.07
5 ± 0.04
5.91 ± 0.12
5.69 ± 0.15
6.34 ± 0.34
5.98 ± 0.19
TG (mmol/l)
1.35 ± 0.04
1.15 ± 0.05
1.62 ± 0.06
1.55 ± 0.09
1.67 ± 0.11
1.69 ± 0.12
TC (mmol/l)
4.73 ± 0.05
4.45 ± 0.08
4.98 ± 0.07
4.96 ± 0.01
5.06 ± 0.13
4.97 ± 0.13
HDL-C (mmol/l)
1.18 ± 0.02
1.26 ± 0.03
1.11 ± 0.02
1.18 ± 0.03
1 ± 0.05§
1.07 ± 0.03
LDL-C (mmol/l)
2.9 ± 0.05
2.67 ± 0.07
3.16 ± 0.07
3.08 ± 0.11
3.29 ± 0.14
3.23 ± 0.14
ApoA1 (g/l)
1.67 ± 0.01
1.65 ± 0.02
1.68 ± 0.02
1.67 ± 0.03
1.7 ± 0.05
1.69 ± 0.03
ApoB (g/l)
0.9 ± 0.01
0.87 ± 0.02
0.93 ± 0.02
0.93 ± 0.03
0.96 ± 0.04
0.89 ± 0.03
Microvascular function
FSBFmax (%)
595 ± 52.45
914.25 ± 77.43
299.8 ± 41.0
377.9 ± 68.38
226.71 ± 89.5
243.25 ± 56.73
FSBFRHS (%)
1047.51 ± 65.78
946.02 ± 94.2
1139.6 ± 90.87
990.31 ± 138.7
1390 ± 228.2
1226.43 ± 137.02
AUC (PUSec)
6623.8 ± 515.9
8168.6 ± 833.26
5307.84 ± 590.46
4863.54 ± 905.62
5424.45 ± 655.51
5723.01 ± 903.45
Basal CVC (PU/mmHg)
0.07 ± 0.007
0.09 ± 0.01
0.05 ± 0.003
0.06 ± 0.01
0.05 ± 0.01
0.06 ± 0.006
Peak ACh-CVC (PU/mmHg)
0.4 ± 0.03
0.48 ± 0.004
0.3 ± 0.03
0.26 ± 0.05
0.43 ± 0.18
0.32 ± 0.05
Peak RHS-CVC (PU/mmHg)
0.55 ± 0.02
0.59 ± 0.04
0.51 ± 0.03
0.67 ± 0.17
0.47 ± 0.06
0.53 ± 0.05
ΔACh-CVC (PU/mmHg)
0.32 ± 0.03
0.41 ± 0.04
0.25 ± 0.03
0.23 ± 0.05
0.41 ± 0.18
0.24 ± 0.05
ΔRHS-CVC (PU/mmHg)
0.46 ± 0.02
0.48 ± 0.0.04
0.44 ± 0.03
0.4 ± 0.06
0.43 ± 0.15
0.48 ± 0.05
(in nonobese versus obese subjects). § (in obese class I versus obese class II). # (in obese class I versus obese class III (morbid)). ǂ (in obese class II versus obese class III). ApoA1: apolipoprotein A1; ApoB: apolipoprotein B; AUC: area under the curve; BMI: body mass index; basal CVC: cutaneous vascular conductance; DBP: diastolic blood pressure; FG: fasting glucose; FSBFmax: maximum forearm skin blood flow; FSBFRHS: forearm skin blood flow response to heating the skin; HC: hip circumference; HDL-C: high-density lipoprotein cholesterol; hs-CRP: high-sensitivity C reactive protein; LDL-C: low-density lipoprotein cholesterol; MAP: mean arterial pressure; PU: perfusion unit; SBP: systolic blood pressure; TC: total cholesterol; TG: triglycerides. Data are expressed as mean ± SD.
