Disease Markers

Research Article

Association of Single-Nucleotide Polymorphisms in DC-SIGN with Nasopharyngeal Carcinoma Susceptibility

Table 5

Frequencies of genotypes at DC-SIGN rs735240 in NPC patients and healthy controls.


Genotype	Cases	Controls	Unadjusted OR (95%CI)	P	Adjusted OR(95%CI)	Adjusted P	Adjusted OR^▲ (95%CI)	Adjusted P	P_HWE

rs735240									0.937
AA	24	28	1.000		1.000		1.000
AG	161	193	0.973 (0.543–1.745)	0.927	1.044 (0.574–1.901)	0.887	2.976 (1.123–7.888)	0.028
GG	292	339	1.005 (0.570–1.772)	0.986	1.077 (0.601–1.927)	0.804	3.314 (1.274–8.622)	0.014
AG + GG	453	532	0.993 (0.568–1.738)	0.982	1.065 (0.600–1.891)	0.830	3.191 (1.237–8.230)	0.016

Calculated using multiple logistic regression after controlling for age, sex, and smoking history; ^▲calculated using multiple logistic regression after controlling for age, sex, smoking history, and EBV-VCA-IgA status. CI: confidence interval; DC-SIGN: dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin; HWE: Hardy-Weinberg equilibrium; NPC: nasopharyngeal carcinoma; OR: odds ratio.