Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease

Table 3

Multivariable model associating hematologic and biochemical data and gene polymorphisms in TAMMV 75th percentile.

Variables	B	SE	Wald	value	OR	95% CI		R square	model
						Lower	Upper
Model 1
Hematocrit (<33.35%)	2.95	1.47	4.02	0.045	19.25	1.07	346.20	0.432	0.004
RDW (≥15.55%)	−3.79	1.50	6.36	0.012	0.02	0.00	0.42
Ferritin (≥105.75 ηg/mL)	2.09	1.33	2.45	0.117	8.13	0.59	111.87
NOx (<29.86 μM)	3.33	1.58	4.42	0.036	27.99	1.25	625.23
Absence of α^3.7Kb thalassemia	−1.53	1.21	1.59	0.206	0.21	0.02	2.32
CAR haplotype	1.59	1.06	2.25	0.133	4.90	0.61	39.13
MTHFR C677T	−1.85	1.12	2.71	0.100	0.15	0.01	1.42
VCAM T833C	1.73	1.22	2.01	0.155	5.66	0.51	61.91
VCAM G1238C	3.41	1.94	3.10	0.078	30.50	0.68	1368.45

B: beta coefficient; SE: standard error; OR: odds ratio; CI: confidence interval; RDW: red cell distribution width; NOx: nitric oxide metabolites; defined as variant allele T presence; defined as variant allele C presence; defined as variant allele C presence; TAMMV 75th percentile as a dependent variable defined as TAMMV ≥ 125.75 cm/s; significant values are shown in bold.