Research Article
Hyperferritinemia as a Diagnostic Marker for Severe Fever with Thrombocytopenia Syndrome
Table 1
Comparison of the basal characteristics and laboratory findings in patients with SFTS and bacteremia with thrombocytopenia.
| | | STFS
(, %) | Bacteremia
(, %) | value |
| | Demographic data | | | | | Age | 74 (64–80) | 69 (59–75) | 0.257 | | Male sex | 2 (18) | 25 (40) | 0.195 | | Rural area resident | 9 (82) | 26 (42) | 0.150 | | Comorbidities | 5 (46) | 59 (95) | <0.001 | | Hypertension | 4 (36) | 31 (50) | 0.404 | | Diabetes mellitus | 3 (27) | 24 (39) | 0.736 | | Neurologic disease | 0 (0) | 13 (21) | 0.195 | | Cardiovascular disease | 0 (0) | 11 (18) | 0.197 | | Chronic kidney disease | 1 (9) | 9 (15) | >0.999 | | Liver cirrhosis | 0 (0) | 5 (8) | >0.999 | | Autoimmune disease | 0 (0) | 3 (5) | >0.999 | | Dyslipidemia | 1 (9) | 1 (2) | 0.280 | | Malignancy | 1 (9) | 1 (2) | 0.280 | | Symptom | | | | | Fever (>38°C) | 11 (100) | 37 (60) | 0.012 | | Neurologic symptoms | 5 (46) | 10 (16) | 0.041 | | Mortality | 4 (37) | 18 (29) | 0.724 | | Laboratory results | | | | | White blood cell (/mm3) | 1400 (700–2100) | 11850 (7625–19375) | <0.001 | | Hemoglobin (dL) | 12 (11-12) | 10 (9–12) | 0.024 | | Platelet (×103/mm3) | 43 (35–71) | 70 (47–98) | 0.121 | | PT (sec) | 13 (12–15) | 13 (12–15) | 0.743 | | aPTT (sec) | 59 (51–67) | 47 (40–58) | 0.035 | | Fibrinogen (mg/dL)† | 210 (190–234) | 464 (350–688) | <0.001 | | AST (U/L) | 152 (113–448) | 47 (23–85) | <0.001 | | ALT (U/L) | 88 (39–100) | 26 (13–69) | 0.008 | | LDH (U/L) | 1071 (613–2574) | 593 (419–873) | 0.004 | | Creatine kinase (IU/L)† | 1208 (577–2530) | 118 (45–308) | <0.001 | | CRP (mg/dL) | 1.0 (0.1–1.1) | 18.7 (13.4–26.5) | <0.001 | | Ferritin (ng/mL)† | 10508 (3768–26813) | 597 (303–1169) | <0.001 | | Procalcitonin (ng/mL)† | 0.2 (0.1–0.5) | 22.3 (4.6–76.7) | <0.001 |
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Laboratory data are expressed as the median (interquartile range), unless otherwise specified.
Neurological symptoms include altered mentation, motor weakness, and dysarthria.
†Number of patients for biomarkers: fibrinogen (SFTS 11, bacteremia 52), Creatinine kinase (SFTS 11, bacteremia 60), procalcitonin (SFTS 11, bacteremia 37), and ferritin (SFTS 10, bacteremia 62).
SFTS, severe fever with thrombocytopenia syndrome; PT, prothrombin time; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; CRP, C-reactive protein.
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