Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients

Figure 1

Combined effect of IL-18 rs5744247 and rs1946518 polymorphisms on tacrolimus concentration/dose (C/D) ratios in lung transplant patients at week 1 (a), week 2 (b), week 3 (c), and week 4 (d) following transplantation. IL-18 rs5744247 allele C and rs1946518 allele A were associated with fast tacrolimus metabolism. The lung transplant recipients were divided into 3 groups according to the numbers of these alleles: Group 1 (the number of alleles less than or equal to 1), Group 2 (the number of alleles equal to 2), and Group 3 (the number of alleles greater than or equal to 3). Patients who carried greater than or equal to 3 alleles associated with fast tacrolimus metabolism (Group 3) had lower tacrolimus C/D ratios than the other groups (Kruskal-Wallis test, ).

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