Research Article
Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma
Table 4
The influence of MMP9 haplotypes on time to progression and overall survival.
| Haplotype | Estimated frequency | TTP HR (95% CI) | | OS HR (95% CI) | |
| ACGT | 0.560 | Reference | | Reference | | GCGC | 0.214 | 0.98 (0.74–1.29) | 0.877 | 0.97 (0.73–1.30) | 0.853 | GCAC | 0.129 | 1.13 (0.81–1.58) | 0.460 | 0.96 (0.68–1.37) | 0.830 | ACGC | 0.053 | 1.33 (0.81–2.18) | 0.261 | 1.85 (1.12–3.05) | 0.016 | AGGC | 0.024 | 2.14 (1.03–4.44) | 0.042 | 2.07 (1.02–4.22) | 0.045 | AGAC | 0.020 | 2.93 (1.30–6.60) | 0.010 | 3.38 (1.33–8.54) | 0.010 |
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The SNPs are ordered from the 5- to 3-end as follows: rs17576, rs2250889, rs17577, and rs20544.
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