Matrix Metalloproteinases Polymorphisms as Prognostic Biomarkers in Malignant Pleural Mesothelioma

Table 4

The influence of MMP9 haplotypes on time to progression and overall survival.

Haplotype	Estimated frequency	TTP HR (95% CI)		OS HR (95% CI)
ACGT	0.560	Reference		Reference
GCGC	0.214	0.98 (0.74–1.29)	0.877	0.97 (0.73–1.30)	0.853
GCAC	0.129	1.13 (0.81–1.58)	0.460	0.96 (0.68–1.37)	0.830
ACGC	0.053	1.33 (0.81–2.18)	0.261	1.85 (1.12–3.05)	0.016
AGGC	0.024	2.14 (1.03–4.44)	0.042	2.07 (1.02–4.22)	0.045
AGAC	0.020	2.93 (1.30–6.60)	0.010	3.38 (1.33–8.54)	0.010

The SNPs are ordered from the 5- to 3-end as follows: rs17576, rs2250889, rs17577, and rs20544.