Early Right Ventricular Apical Pacing-Induced Gene Expression Alterations Are Associated with Deterioration of Left Ventricular Systolic Function
Table 2
LVEF and strain parameters in the RVA pacing and RVOT pacing groups during the follow-up.
Variables
RVA
RVOT
Value
LVEF (%)
Baseline
63.0 ± 5.4
62.4 ± 6.1
0.704
1 month
61.8 ± 5.3
61.3 ± 5.2
0.678
6 months
60.5 ± 5.8
61.5 ± 5.4
0.506
12 months
59.4 ± 6.5
61.1 ± 5.1
0.258
24 months
56.7 ± 7.6#
60.4 ± 5.3
0.034
GLS (%)
Baseline
−13.1 ± 2.5
−12.9 ± 3.0
0.746
1 month
−12.9 ± 2.7
−12.5 ± 3.0
0.639
6 months
−12.7 ± 2.8
−12.4 ± 3.4
0.510
12 months
−10.6 ± 2.8#
−12.3 ± 3.6
0.044
24 months
−9.9 ± 3.0#
−12.1 ± 3.7
0.015
GRS (%)
Baseline
29.7 ± 5.7
28.2 ± 5.2
0.311
1 month
29.4 ± 6.2
28.1 ± 5.3
0.385
6 months
28.4 ± 6.4
28.1 ± 5.4
0.547
12 months
27.9 ± 6.5#
27.8 ± 5.5
0.966
24 months
25.9 ± 6.6#
27.3 ± 6.3
0.392
GCS (%)
Baseline
−20.8 ± 4.4
−19.8 ± 5.5
0.441
1 month
−20.5 ± 4.6
−19.7 ± 5.6
0.502
6 months
−20.1 ± 5.1
−19.4 ± 5.9
0.622
12 months
−19.2 ± 5.4#
−19.0 ± 6.0
0.875
24 months
−15.7 ± 5.6#
−18.6 ± 6.6
0.078
SDI (%)
Baseline
12.2 ± 2.0
12.3 ± 2.1
0.852
1 month
12.8 ± 2.4
12.7 ± 2.5
0.876
6 months
13.1 ± 2.3
13.0 ± 2.6
0.959
12 months
15.5 ± 2.4#
13.1 ± 2.7
0.001
24 months
16.4 ± 3.5#
13.5 ± 2.7
0.001
LVEF: ejection fraction left ventricular; RVA: right ventricular apical; RVOT: right ventricular outflow tract; GLS: global longitudinal strain; GRS: global radial strain; GCS: global circumferential strain; SDI: standard deviation index of three-dimensional strain. versus baseline in the same group; # versus 1 month in the same group.
