Early Right Ventricular Apical Pacing-Induced Gene Expression Alterations Are Associated with Deterioration of Left Ventricular Systolic Function

Table 3

Multivariate linear regression analysis for the changes in mRNA levels of OPA1 and SERCA2a.

Variables	Model (OPA1)				Model (SERCA2a)
	β	95% CI	95% CI	value	β	95% CI	95% CI	value
		Lower	Upper			Lower	Upper
Delta GLS	−0.066	−0.089	−0.044	<0.001	−0.029	−0.34	−0.178	<0.001
Delta GCS	−0.006	−0.033	0.021	0.639	−0.059	−0.156	0.046	0.271
Delta GRS	0.007	−0.026	0.04	0.654	−0.005	−0.130	0.120	0.993
Delta SDI	−0.034	−0.005	−0.012	0.004	−0.138	−0.217	−0.059	0.001
Delta LVEF	0.017	0.008	0.025	<0.001	0.074	0.046	0.103	<0.001

LVEF: ejection fraction left ventricular; GLS: global longitudinal strain; GRS: global radial strain; GCS: global circumferential strain; SDI: standard deviation index of three-dimensional.