Early Right Ventricular Apical Pacing-Induced Gene Expression Alterations Are Associated with Deterioration of Left Ventricular Systolic Function

Table 4

Multivariate linear regression analysis for the changes in mRNA levels of OPA1 and SERCA2a.

Variables	Model (OPA1)				Model (SERCA2a)
	Adjusted R-square = 0.511				Adjusted R-square = 0.538
	β	95% CI	95% CI	value	β	95% CI	95% CI	value
		Lower	Upper			Lower	Upper
Delta GLS	−0.090	−0.145	−0.036	0.002	−0.229	−0.427	−0.030	0.026
Delta GCS	0.010	−0.010	0.031	0.317	0.003	−0.072	0.790	0.930
Delta GRS	−0.002	−0.027	0.023	0.895	−0.038	−0.130	0.053	0.393
Delta SDI	−0.005	−0.033	0.023	0.724	−0.020	−0.123	0.083	0.692
Delta LVEF	−0.009	−0.026	0.008	0.283	0.006	−0.056	0.068	0.848

LVEF: ejection fraction left ventricular; GLS: global longitudinal strain; GRS: global radial strain; GCS: global circumferential strain; SDI: standard deviation index of three-dimensional.