Peritransplant Soluble CD30 as a Risk Factor for Slow Kidney Allograft Function, Early Acute Rejection, Worse Long-Term Allograft Function, and Patients’ Survival
Table 5
Significant predictors of eGFR at different time points of posttransplant period.
Predictive variables
Univariate linear regression
Multivariate linear regression
Beta
SE
value
Beta
SE
value
eGFR at 1 month (mL/min/1.73 m2)
Deceased-donor graft
−0.333
0.144
0.025
Impaired initial function
−0.660
0.115
<0.001
−0.616
0.115
<0.001
eGFR at 3 months (mL/min/1.73 m2)
Recipient age
−0.370
0.143
0.013
−0.190
0.144
0.192
Pretransplant sCD30
0.313
0.147
0.038
0.145
0.141
0.309
Impaired initial function
−0.509
0.133
<0.001
−0.417
0.137
0.004
eGFR at 6 months (mL/min/1.73 m2)
Recipient age
−0.341
0.145
0.024
Pretransplant sCD30
0.316
0.146
0.037
0.291
0.131
0.032
Impaired initial function
−0.448
0.138
0.002
−0.378
0.129
0.005
Previous AR
−0.317
0.146
0.036
−0.366
0.127
0.006
eGFR at 1 year (mL/min/1.73 m2)
Early AR
−0.321
0.150
0.038
−0.232
0.147
0.123
Serum creatinine at discharge
−0.355
0.148
0.021
−0.237
0.153
0.129
Deceased-donor graft
−0.325
0.150
0.036
−0.206
0.152
0.182
eGFR at 2 years (mL/min/1.73 m2)
Posttransplant sCD30
0.417
0.178
0.027
0.382
0.161
0.026
Serum creatinine at discharge
−0.413
0.179
0.029
−0.342
0.167
0.052
Deceased-donor graft
−0.392
0.180
0.039
−0.232
0.169
0.184
eGFR at 3 years (mL/min/1.73 m2)
AR at any time
−0.353
0.156
0.030
−0.197
0.141
0.172
Previous transplants
−0.489
0.145
0.002
−0.415
0.137
0.005
Serum creatinine at discharge
−0.396
0.153
0.014
−0.294
0.139
0.043
eGFR at 4 years (mL/min/1.73 m2)
Serum creatinine at discharge
−0.432
0.155
0.008
−0.413
0.147
0.008
Pyelonephritis (8th day–2 months)
−0.349
0.167
0.037
−0.324
0.147
0.034
eGFR at 5 years (mL/min/1.73 m2)
Serum creatinine at discharge
−0.389
0.156
0.018
−0.287
0.161
0.079
Second warm ischemia
−0.391
0.156
0.017
−0.292
0.161
0.083
eGFR: estimated glomerular filtration rate; beta: standardized regression coefficient; SE: standard error of beta; sCD30: soluble CD30; AR: acute rejection. Only variables that significantly influenced the eGFR in univariate analysis are included.
