The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker
Table 1
Relationship between tissue hsa_circ_0001445 expression (ΔCt) and clinical characteristics of HCC patients.
Characteristics
Patient number
Mean ± SD
value
Tissues
<0.001
HCC
73
8.50 ± 0.32
Adjacent
73
6.77 ± 0.77
Gender
0.441
Female
6
8.41 ± 0.34
Male
67
9.34 ± 0.97
Age
0.100
<54
35
9.09 ± 0.45
≥54
38
8.01 ± 0.49
Smoking
0.562
Positive
42
8.43 ± 0.43
Negative
22
8.01 ± 0.56
Alcoholism
0.802
Positive
26
7.99 ± 0.54
Negative
32
8.48 ± 0.37
Tumor size
0.734
<5 cm
15
8.77 ± 0.48
≥5 cm
54
6.23 ± 0.41
Tumor foci
0.014
=1
32
7.30 ± 0.49
>1
9
9.63 ± 0.70
TNM
0.185
I/II
21
9.02 ± 0.36
III/IV
40
8.16 ± 0.53
Differentiation
0.163
High/moderate
56
8.25 ± 0.40
Low
15
9.39 ± 0.42
ALT
0.179
Negative
42
8.87 ± 0.41
Positive
31
7.99 ± 0.50
AST
0.798
Negative
35
8.58 ± 0.43
Positive
32
8.41 ± 0.48
AFP
0.339
Negative
35
8.13 ± 0.52
Positive
35
8.77 ± 0.41
The data are presented as mean ± S.E.M. ,. The ΔCt value was determined by subtracting the Ct value of GAPDH from the Ct value of the circRNA. A larger ΔCt value indicates a lower expression. HCC: hepatocellular carcinoma; TNM: tumor-node metastasis; ALT: alanine aminotransferase; AST: aspartate aminotransferase; AFP: alpha-fetoprotein.
