The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker
Table 2
Relationship between plasma hsa_circ_0001445 expression (ΔCt) and clinical characteristics of HCC patients.
Characteristics
Patient number
Mean ± SD
value
Plasma
<0.001
HCC
55
1.02 ± 0.17
Healthy controls
44
−0.70 ± 0.23
Gender
0.202
Male
87
1.13 ± 0.21
Female
17
0.45 ± 0.50
Age
0.197
<59
52
1.08 ± 0.15
≥59
52
1.25 ± 0.17
ALT
0.272
Negative
61
0.99 ± 0.13
Positive
43
1.15 ± 0.20
AST
0.959
Negative
23
1.03 ± 0.28
Positive
32
1.01 ± 0.28
GGT
0.414
Negative
35
0.96 ± 0.17
Positive
69
1.17 ± 0.15
GLU
0.486
<6.1
84
1.14 ± 0.13
≥6.1
19
0.93 ± 0.27
AFP
0.009
Negative
43
1.46 ± 0.15
Positive
61
0.85 ± 0.16
CEA
0.359
Negative
93
1.06 ± 0.12
Positive
11
1.40 ± 0.34
Ca199
0.113
Negative
83
1.01 ± 0.23
Positive
21
1.46 ± 0.42
Ca125
0.231
Negative
72
1.01 ± 0.13
Positive
32
1.31 ± 0.27
HBV
0.210
<500
53
1.25 ± 0.19
≥500
51
0.96 ± 0.14
The data are presented as mean ± S.E.M. . The ΔCt value was determined by subtracting the Ct value of GAPDH from the Ct value of the circRNA. A larger ΔCt value indicates a lower expression. HCC: hepatocellular carcinoma; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: γ-glutamyl transferase; GLU: glucose; AFP: alpha-fetoprotein; HBV: hepatitis B virus.
