Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis

Figure 4

(a) Expression level of TP53 in cancer and normal tissues. GBM: glioblastoma multiforme; LGG: brain lower grade glioma; . (b) Expression level of DLG4 in cancer and normal tissues; . (c) The correlation analysis between TP53 and CDK2. TP53 and CDK2 are obviously positively correlated. (d) The correlation analysis between DLG4 and ADAM22. DLG4 and ADAM22 are obviously positively correlated. (e) TP53 protein was strongly upregulated in glioma tissues compared with normal brain tissues based on the Human Protein Atlas database. The normal brain tissue of TP53 was from a male, age 62, (patient ID: 1609; staining: not detected; intensity: negative; quantity: negative; location: none), and the glioma tissue was from a male, age 61, (patient ID: 2522; staining: high; intensity: strong; quantity: >75%; location: nuclear). (f) DLG4 protein was strongly downregulated in glioma tissues compared with normal brain tissues based on the Human Protein Atlas database. The normal brain tissue of DLG4 was from a male, age 45, (patient ID: 2521; staining: medium; intensity: moderate; quantity: >75%; location: membranous nuclear), and the glioma tissue was from a male, age 48 (patient ID: 3092; staining: not detected; intensity: negative; quantity: negative; location: none).

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