Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples

Figure 1

Identification of DEPs and DEGs between tumor and nontumor samples. (a–c) Volcano plot of the differential mRNA expression analysis. x-axis: log2 fold change; y-axis: −log10 (FDR value) for each probe; vertical dotted lines: fold change ≥ 2 or ≤2; horizontal dotted line: the significance cutoff (FDR value = 0.05). (a) There were 2802 genes identified to be differentially expressed in GSE21510, including 1623 upregulated and 1179 downregulated genes. (b) There were 911 genes identified to be differentially expressed in GSE23878, including 284 upregulated and 627 downregulated genes. (c) There were 1436 genes identified to be differentially expressed in GSE32323, including 717 upregulated and 719 downregulated genes. (d–e) Overlap analysis of upregulated genes and downregulated genes between different datasets. (d) A total of 181 genes were significantly upregulated in the three colorectal cancer datasets. (e) A total of 282 genes were significantly downregulated in the three colorectal cancer datasets.

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