Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples

Table 2

Pathway analysis of DEGs between paired tumor and nontumor samples.

Expression	Pathway	Count	Term/gene function	%	value
Upregulated	hsa04110: Cell cycle	11	CCNB1, CDK1, CDC6, MAD2L1, TTK, BUB1B, ORC6, MCM2, PTTG1, CDK4, CDC25B	4.13	2.90E − 07
	hsa04115: p53 signaling pathway	4	CCNB1, CDK1, RRM2, CDK4	1.50	0.028
	hsa03030: DNA replication	3	RFC3, MCM2, RNASEH2A	1.13	0.049
Downregulated	hsa04978: mineral absorption	9	SLC26A3, TRPM6, MT1M, MT2A, CYBRD1, MT1E, MT1H, MT1X, MT1F	2.40	8.10E − 07
	hsa00910: nitrogen metabolism	5	CA12, CA7, CA4, CA2, CA1	1.33	1.57E − 04
	hsa04976: bile secretion	7	AQP8, PRKACB, SLC51B, CA2, SLC51A, SLC4A4, ABCG2	1.87	0.001
	hsa00830: retinol metabolism	6	ALDH1A1, ADH1C, DHRS9, ADH1B, UGT2A3, RETSAT	1.60	0.005
	hsa04964: proximal tubule Bicarbonate reclamation	4	CA4, CA2, SLC4A4, PCK1	1.07	0.007
	hsa04972: pancreatic secretion	6	SLC26A3, CLCA1, CLCA4, PLA2G10, CA2, SLC4A4	1.60	0.020
	hsa00040: pentose and glucuronate interconversions	4	AKR1B10, UGDH, UGT2A3, UGP2	1.07	0.023
	hsa04924: renin secretion	5	CLCA1, CLCA4, GNAI1, PDE3A, PRKACB	1.33	0.023
	hsa04960: aldosterone-regulated sodium reabsorption	4	SGK1, NR3C2, HSD11B2, SCNN1B	1.07	0.028
	hsa04530: tight junction	7	CLDN8, EPB41L3, GNAI1, MYH11, JAM2, CLDN23, MYL9	1.87	0.028
	hsa05204: chemical carcinogenesis	5	NAT2, ADH1C, ADH1B, SULT1A2, UGT2A3	1.33	0.046
	hsa04670: leukocyte transendothelial migration	6	CLDN8, GNAI1, JAM2, CXCL12, CLDN23, MYL9	1.60	0.049
	hsa05030: cocaine addiction	4	GNAI1, MAOA, PRKACB, FOSB	1.07	0.050