Haplotypes of TNFα/β Genes Associated with Sex-Specific Paranoid Schizophrenic Risk in Tunisian Population
Table 2
Distribution of genotype frequencies of rs909253, rs1799724, and rs361525 between controls and patients according to the different models of inheritance.
Controls (%)
Patients (%)
value
OR (95% CI)
AIC
rs909253
Codominant
AA
111 (53.4)
84 (40.4)
1
AG
79 (38)
93 (44.7)
0.03
1.55 (1.02–2.35)
GG
18 (8.6)
31 (14.9)
0.01
2.26 (1.19–4.40)
574.3
Dominant
AA
111 (53.4)
84 (40.4)
1
AG+GG
97 (46.6)
124 (59.6)
0.008
1.68 (1.14–2.49)
573.6
Recessive
AA+AG
190 (91.4)
177 (85.1)
1
GG
18 (8.6)
31 (14.9)
0.049
1.84 (1.001–3.47)
576.7
rs1799724
Codominant
CC
170 (81.7)
147 (70.7)
1
CT
35 (16.8)
54 (26)
0.01
1.78 (1.1–2.89)
TT
3 (1.5)
7 (3.3)
0.1
2.69 (0.69–13.01)
575.3
Dominant
CC
170 (81.7)
147 (70.7)
1
CC+CT
38 (18.3)
61 (29.3)
0.008
1.85 (1.17–2.95)
573.6
Recessive
CC+CT
205 (98.5)
201 (96.6)
1
TT
3 (1.5)
7 (3.4)
0.2
2.37 (0.61–11.44)
579
rs361525
Codominant
GG
104 (50)
62 (29.8)
1
GA
80 (38.5)
110 (52.9)
0.0001
2.30 (1.50–3.53)
AA
24 (11.5)
36 (17.3)
0.002
2.50 (1.37–4.63)
564.9
Dominant
GG
104 (50)
62 (29.8)
1
GA+AA
104 (50)
146 (70.2)
0.00002
2.35 (1.57–3.52)
562.9
Recessive
GG+GA
184 (88.5)
172 (82.7)
1
AA
24 (11.5)
36 (17.3)
0.09
0.62 (0.35–1.08)
577.9
. The chi-square test was used to evaluate the significant association between disease (schizophrenia against controls) and TNFA or LTA alleles or genotypes. AIC (Akaike information criterion) provides a means for model selection.
