Haplotypes of TNFα/β Genes Associated with Sex-Specific Paranoid Schizophrenic Risk in Tunisian Population

Table 4

Distribution of genotype and allele frequencies of rs909253, rs1799724, and rs361525 in control subjects and paranoid-type patients according to onset age.

	Genotype (%)		value (OR)	Allele (%)		value (OR)
rs909253	AA	AG+GG		A	G
Controls	111 (53.4)	97 (46.6)		301 (72.4)	115 (27.6)
Paranoid type ≤ 21 yrs ()	9 (39.1)	14 (60.9)	0.2 (1.77)	26 (56.5)	20 (43.5)	0.03 (2.01)
Paranoid type > 21 yrs ()	23 (39)	36 (61)	0.05 (1.78)	73 (61.9)	45 (38.1)	0.03 (1.6)
rs1799724	CC	CT+TT		C	T
Controls	170 (81.7)	38 (18.3)		375 (90.2)	41 (9.8)
Paranoid type ≤ 21 yrs ()	13 (56.5)	10 (43.5)	0.01 (3.41)	34 (73.9)	12 (26.1)	0.003 (3.2)
Paranoid type > 21 yrs ()	32 (54.2)	27 (45.8)	(3.75)	89 (75.4)	29 (24.6)	(2.9)
rs361525	GG	GA+AA		G	A
Controls	104 (50)	104 (50)		288 (69.2)	128 (30.8)
Paranoid type ≤ 21 yrs ()	5 (21.7)	18 (78.3)	0.01 (3.58)	24 (52.2)	22 (47.8)	0.02 (2.05)
Paranoid type > 21 yrs ()	12 (20.3)	47 (79.7)	(3.89)	57 (48.3)	61 (51.7)	(2.4)

. highly significant.