Amino Acid-Based Metabolic Panel Provides Robust Prognostic Value Additive to B-Natriuretic Peptide and Traditional Risk Factors in Heart Failure

Figure 1

Diagnostic value of amino acid-based metabolic profile and B-natriuretic peptide (BNP). (a) The receiver operating characteristic curves and area under the curves. (b and c) The HOP and log (BNP) at different heart failure (HF) stages. , compared to normal controls (N); ^†, compared to stage A; ‡, compared to stage B; ^#, compared to stage C. (d) Log (BNP) and HOP in patients with atrial fibrillation (af), age > 70 years, body mass index , and estimated glomerular filtration rate . , compared to stage B; ^†, compared to stage C. HOP: a metabolic panel composed of histidine, ornithine, and phenylalanine.

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