Anti-Double-Stranded DNA Isotypes and Anti-C1q Antibody Improve the Diagnostic Specificity of Systemic Lupus Erythematosus

<table class="table-group" id="tab7"><tr><td><table class="table"><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr class="thead"><td class="align_left"></td><td class="align_center">Sensitivity</td><td class="align_center">Specificity</td><td class="align_center">PPV</td><td class="align_center">NPV</td><td class="align_center">OR (95% CI)</td></tr><tr><td class="thead-hr" colspan="6"><hr/></td></tr><tr><td class="align_left">Anti-C1q</td><td class="align_center">59%</td><td class="align_center">63%</td><td class="align_center">64%</td><td class="align_center">58%</td><td class="align_center">2.407 (1.001–5.793)</td></tr><tr><td class="align_left">Anti-dsDNA IgM negative</td><td class="align_center">70%</td><td class="align_center">59%</td><td class="align_center">69%</td><td class="align_center">64%</td><td class="align_center">3.316 (1.427–7.702)</td></tr><tr><td class="align_left">Anti-C1q positive and anti-dsDNA IgM negative</td><td class="align_center">34%</td><td class="align_center">96%</td><td class="align_center">90%</td><td class="align_center">57%</td><td class="align_center">11.333 (2.446–52.502)</td></tr><tr class="table-tr"><td colspan="6"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>SLE: systemic lupus erythematosus; PPV: positive predictive value; NPV: negative predictive value; OR: odds ratio; CI: confidence interval.<br/></div></td></tr></table>

<div>Diagnostic value of anti-dsDNA isotypes and anti-c1q antibody for lupus nephritis.</div>

Disease Markers

tab7

Table 7

Table 7: Anti-Double-Stranded DNA Isotypes and Anti-C1q Antibody Improve the Diagnostic Specificity of Systemic Lupus Erythematosus 