Research Article
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Table 1
Background and physiological parameters throughout the experiment.
| | Control | Hypoxia + NACA | Hypoxia + saline |
| | Weight (g) | 1923 (±76) | 1874 (±184) | 1924 (±124) | | Hypoxia time (min) | 33 (±12) | 40 (±13) | 33 (±12) | | Hb g/100 ml start | 7.7 (±1.8) | 8.0 (±1.2) | 7.0 (±1.0) | | Hb g/100 ml end | 5.9 (±1.2) | 6.3 (±0.8) | 7.1 (±2.7) | | Gender (male/female) | 3/2 | 6/6 | 6/6 | | pH | | Start | 7.44 (±0.04) | 7.42 (±0.04) | 7.45 (±0.04) | | End hypoxia | 7.43 (±0.05) | 6.87 (±0.08) | 6.92 (±0.11) | | 30 min reox | 7.46 (±0.04) | 7.18 (±0.09) | 7.18 (±0.07) | | 90 min reox | 7.45 (±0.06) | 7.45 (±0.04) | 7.35 (±0.08) | | 270 min reox | 7.42 (±0.12) | 7.45 (±0.04) | 7.39 (±0.10) | | 570 min reox | 7.38 (±0.06) | 7.42 (±0.04) | 7.39 (±0.09) | | BE (mmol/l) | | Start | 4.3 (±2.9) | −0.5 (±4.9) | −0.3 (±3.6) | | End hypoxia | 4.1 (±3.6) | −18.9 (±2.2) | −19.0 (±3.9) | | 30 min reox | 4.4 (±1.9) | −13.3 (±4.7) | −15.1 (±3.5) | | 90 min reox | 4.2 (±2.3) | −3.9 (±5.0) | −5.7 (±4.6) | | 270 min reox | 2.9 (±4.5) | −2.2 (±4.4) | −1.4 (±5.0) | | 570 min reox | 0.5 (±3.4) | −6.5 (±6.6) | −3.7 (±5.4) | | Lactate (mmol/l) | | Start | 2.3 (±1.1) | 2.3 (±1.1) | 2.8 (±1.0) | | End hypoxia | 2.4 (±2.1) | 14.3 (±2.7) | 13.2 (±3.1) | | 30 min reox | 1.8 (±1.1) | 10.7 (±3.8) | 11.2 (±0.6) | | 90 min reox | 1.5 (±0.6) | 5.9 (±2.2) | 6.3 (±2.1) | | 270 min reox | 1.3 (±0.4) | 1.7 (±0.8) | 2.3 (±2.2) | | 570 min reox | 1.7 (±1.0) | 1.4 (±1.0) | 2.1 (±2.0) | | Glucose (mmol/l) | | Start | 5.0 (±1.2) | 6.4 (±2.1) | 6.7 (±2.3) | | End hypoxia | 5.0 (±1.5) | 9.6 (±3.4) | 9.1 (±3.7) | | 30 min reox | 4.7 (±0.8) | 8.0 (±3.5) | 7.5 (±3.6) | | 90 min reox | 4.9 (±0.6) | 6.5 (±2.3) | 6.7 (±2.3) | | pCO2 (kPa) | | Start | 5.0 (±1.1) | 5.2 (±0.9) | 5.0 (±1.1) | | End hypoxia | 5.7 (±0.3) | 8.4 (±1.4) | 7.7 (±1.1) | | 30 min reox | 5.4 (±0.6) | 5.1 (±0.8) | 4.4 (±0.6) |
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