A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease

Table 1

Demographic and clinical data of the study participants.

Baseline characteristics	Controls,	CAD patients,	value
Age, mean ± SD	58.8 ± 7.6	59.5 ± 10.3	0.16
Males	404 (58.9)	401 (63.0)	0.13
BMI (kg/m^2), mean ± SD	27.9 ± 10.2	28.8 ± 9.4	0.10
Hypertension	0 (0.0)	842 (90.2)	—
Diabetes	0 (0.0)	79 (8.5)	—
Fasting blood glucose (mmol/L)^1	5.2 ± 0.7	8.1 ± 0.5	<0.0001
TC (mmol/L)^1	4.2 ± 0.3	6.2 ± 0.4	<0.0001
HDL-C (mmol/L)^1	1.2 ± 0.2	1.1 ± 0.3	<0.0001
LDL-C (mmol/L)^1	3.1 ± 0.3	4.3 ± 0.6	<0.0001
TG (mmol/L)^1	1.5 ± 0.4	1.7 ± 0.3	<0.0001
Smokers (ever/never)^2	273 (41.5)	251 (43.5)	0.48
Positive family history of CAD	150 (23.8)	323 (34.6)	<0.0001
Positive family history of hypertension	100 (15.9)	273 (29.2)	<0.0001
Positive family history of diabetes	24 (3.8)	127 (13.6)	<0.0001

¹The biochemical parameters were available from 347 subjects of the control group. ²Data on smoking status were not available from 60 CAD patients and 28 controls. SD: standard deviation; BMI: body mass index (age and BMI were normally distributed and were analyzed by Student’s t-test); TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride. Other data are expressed as frequencies and percentages and were evaluated by the χ² test. Bolded is statistically significant value.