A Novel Polymorphism in the Promoter of the CYP4A11 Gene Is Associated with Susceptibility to Coronary Artery Disease
Table 2
Genotype and allele frequencies for SNPs of CYP4A11 and CYP4F2 in patients with CAD and healthy controls.
Gene, polymorphism
Genotype, allele
Controls, (%)1
CAD patients, (%)1
OR (95% CI)2
value
value
CYP4A11, C>G (rs3890011)
C/C
404 (58.9)
338 (53.1)
1.00
0.086
0.22
C/G
236 (34.4)
244 (38.3)
1.21 (0.91–1.58)
G/G
46 (6.7)
55 (8.6)
1.40 (0.92–2.23)
G
328 (23.9)
354 (27.8)
1.21 (1.02–1.48)
0.02
0.05
CYP4A11, T>C (rs9332978)
T/T
542 (79)
459 (72.3)
1.00
0.008
0.04
T/C
134 (19.5)
158 (24.9)
1.42 (1.09–1.84)
C/C
10 (1.5)
18 (2.8)
2.26 (1.04–4.95)
C
154 (11.2)
194 (15.3)
1.44 (1.16–1.81)
0.002
0.01
CYP4A11, A>G (rs9333029)
A/A
526 (76.9)
477 (74.9)
1.00
0.43
0.72
A/G
158 (23.1)
160 (25.1)
1.09 (0.78–1.59)
G/G
0 (0.0)
0 (0.0)
—
G
158 (11.5)
160 (12.6)
1.04 (0.80–1.43)
0.42
0.70
CYP4F2, A>G (rs3093098)
A/A
479 (69.8)
448 (70.3)
1.00
0.89
0.91
A/G
186 (27.1)
172 (27)
0.97 (0.76–1.27)
G/G
21 (3.1)
17 (2.7)
0.85 (0.43–1.68)
G
228 (16.6)
206 (16.2)
0.96 (0.80–1.17)
0.76
0.76
CYP4F2, G>A (rs1558139)
G/G
200 (29.1)
192 (30.1)
1.00
0.91
0.91
G/A
336 (49)
312 (49)
0.98 (0.73–1.28)
A/A
150 (21.9)
133 (20.9)
0.94 (0.70–1.29)
A
636 (46.4)
578 (45.4)
0.97 (0.80–1.18)
0.61
0.76
1Absolute number and percentage of individuals/chromosomes with particular genotype/allele. 2Odds ratio with 95% confidence intervals adjusted for age, gender, BMI, hypertension, diabetes, and smoking.
