MEGF10, a Glioma Survival-Associated Molecular Signature, Predicts IDH Mutation Status

Figure 2

MEGF10 mRNA expression was related to clinical outcomes in gliomas. (a) By Spearman correlation analysis, mRNA expression of MEGF10 was negatively correlated with methylation levels in different WHO grades of glioma. (b) Spearman correlation analysis revealed the correlations between methylation levels and expressions in different WHO grades and different IDH mutation statuses. The correlation was affected by IDH mutation status in all WHO grades. (c, d) Kaplan-Meier estimates of survival for 407 patients in TCGA with RNA-seq. There is a significant difference in survival between MEGF10 high-expression and low-expression patients (LGG, ; GBM, ).

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